PubMed abstract WAF1/CIP1
abstract also posted in the files section of the K9Kitchen discussion group

Monica's Comments
The study looks at ellagic acid, commonly found in items like raspberry and strawberry seeds, and its effects on cancer cells in a laboratory environment (cells in a test tube). They tested cervical carcinoma, and found that at a high concentration, the ellagic acid slowed, then stopped the test cancer. The study does not recommend any dosages, nor does it look at possible side effects -- the focus was in looking to see if ellagic acid had any detectable effect at all.

The full study can be purchased (PDF or HTML) from Science Direct for $30.00.

Abstract
Ellagic acid is a phenolic compound present in fruits and nuts including raspberries, strawberries and walnuts. It is known to inhibit certain carcinogenic induced cancers and may have other chemopreventive properties. The effects of ellagic acid on cell cycle events and apoptosis were studied in cervical carcinoma (CaSki) cells. We found that ellagic acid at a concentration of 10(-5) M induced G arrest within 48 h, inhibited overall cell growth and induced apoptosis in CaSki cells after 72 h of treatment. Activation of the cdk inhibitory protein p21 by ellagic acid suggests a role for ellagic acid in cell cycle regulation of cancer cells.

Study Authors
Narayanan BA, Geoffroy O, Willingham MC, Re GG, Nixon DW.
Cancer Prevention Program, Hollings Cancer Center
Medical University of South Carolina, Charleston 29425, USA.

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